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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Glucocorticoid-Loaded Core-Cross-Linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis
Bart J. Crielaard et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Biocompatible Polyurea Dendrimers with pH-Dependent Fluorescence
Rita B. Restani et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Therapeutic Anti-Methamphetamine Antibody Fragment-Nanoparticle Conjugates: Synthesis and in Vitro Characterization
Nisha Nanaware-Kharade et al.
BIOCONJUGATE CHEMISTRY (2012)
Site-Specific PEGylation at Histidine Tags
Yuehua Cong et al.
BIOCONJUGATE CHEMISTRY (2012)
Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis
Te-Wei Chu et al.
BIOMATERIALS (2012)
Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells
Yan Zhou et al.
BIOMATERIALS (2012)
Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration
Raymond Iezzi et al.
BIOMATERIALS (2012)
FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
James Mu et al.
DIABETES (2012)
Intravitreal pegaptanib combined with diode laser therapy for stage 3+ retinopathy of prematurity in zone I and posterior zone II
Rudolf Autrata et al.
EUROPEAN JOURNAL OF OPHTHALMOLOGY (2012)
Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents
Ricardo P. Garay et al.
EXPERT OPINION ON DRUG DELIVERY (2012)
Polyacetal-stilbene conjugates - The first examples of polymer therapeutics for the inhibition of HIF-1 in the treatment of solid tumours
Richard M. England et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy
Haihua Xiao et al.
JOURNAL OF CONTROLLED RELEASE (2012)
HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity
Tomas Etrych et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Direct Peptide Bioconjugation/PEGylation at Tyrosine with Linear and Branched Polymeric Diazonium Salts
Mathew W. Jones et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
Rong Tong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents
Mathew W. Jones et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Poly(2-oxazoline)s as Polymer Therapeutics
Robert Luxenhofer et al.
MACROMOLECULAR RAPID COMMUNICATIONS (2012)
Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity
Andrew J. Keefe et al.
NATURE CHEMISTRY (2012)
Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model
Sujatha Kannan et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
PHARMACOECONOMIC ASPECTS OF USE OF ERYTHROPOIETIN DRUGS IN PATIENTS ON HEMODIALYSIS IN UKRAINE
N. Bezditko et al.
VALUE IN HEALTH (2012)
Poly[(ethylene oxide)-co-(methylene ethylene oxide)]: A hydrolytically degradable poly(ethylene oxide) platform
Pontus Lundberg et al.
ACS MACRO LETTERS (2012)
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
Jun Fang et al.
ADVANCED DRUG DELIVERY REVIEWS (2011)
Dendrimer-Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells
Ja Hye Myung et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting
Changfeng Wu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus
Ming Yang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells
Kejin Zhou et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Recombinant Protein Hydrazides: Application to Site-Specific Protein PEGylation
Jennifer Thom et al.
BIOCONJUGATE CHEMISTRY (2011)
Arginine-Specific Modification of Proteins with Polyethylene Glycol
Marc A. Gauthier et al.
BIOMACROMOLECULES (2011)
A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours
R. Plummer et al.
BRITISH JOURNAL OF CANCER (2011)
IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance
John B. Mumm et al.
CANCER CELL (2011)
Biomedical applications of dendrimers: a tutorial
Meredith A. Mintzer et al.
CHEMICAL SOCIETY REVIEWS (2011)
Pharmacokinetics and Pharmacodynamics of Pegfilgrastim
Bing-Bing Yang et al.
CLINICAL PHARMACOKINETICS (2011)
Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide
Christopher J. Morris et al.
JOURNAL OF CONTROLLED RELEASE (2011)
The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse
Joseph T. Hardwicke et al.
JOURNAL OF CONTROLLED RELEASE (2011)
G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity
Deborah S. Goldberg et al.
JOURNAL OF CONTROLLED RELEASE (2011)
Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy
Tomas Etrych et al.
JOURNAL OF CONTROLLED RELEASE (2011)
Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery
Jin-Zhi Du et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Polymeric Nanoparticles with Precise Ratiometric Control over Drug Loading for Combination Therapy
Santosh Aryal et al.
MOLECULAR PHARMACEUTICS (2011)
FDA-approved poly(ethylene glycol)-protein conjugate drugs
Steevens N. S. Alconcel et al.
POLYMER CHEMISTRY (2011)
Optimized clinical performance of growth hormone with an expanded genetic code
Ho Cho et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Sortase-catalyzed transformations that improve the properties of cytokines
Maximilian W. Popp et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
HPMA copolymers: Origins, early developments, present, and future
Jindrich Kopecek et al.
ADVANCED DRUG DELIVERY REVIEWS (2010)
Imaging and drug delivery using theranostic nanoparticles
Siti M. Janib et al.
ADVANCED DRUG DELIVERY REVIEWS (2010)
Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities
Ruth Duncan et al.
ADVANCED DRUG DELIVERY REVIEWS (2010)
Gadolinium-Conjugated Dendrimer Nanoclusters as a Tumor-Targeted T-1 Magnetic Resonance Imaging Contrast Agent
Zhiliang Cheng et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System
Mariusz Skwarczynski et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil-Mediated Cross-Linking of Antigens on the Cell Surface
Kuangshi Wu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Katrin Knop et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: The effects of PEGylation degree and drug conjugation style
Saijie Zhu et al.
BIOMATERIALS (2010)
Polypeptide-polymer bioconjugates
Luiz A. Canalle et al.
CHEMICAL SOCIETY REVIEWS (2010)
Phase I Study of NK012, a Novel SN-38-Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors
Tetsuya Hamaguchi et al.
CLINICAL CANCER RESEARCH (2010)
Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery
Youqing Shen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides
Mark E. B. Smith et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Genetically Encoded Initiator for Polymer Growth from Proteins
Jennifer C. Peeler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Combination therapy in multiple sclerosis
Devon Conway et al.
LANCET NEUROLOGY (2010)
Aptamers as therapeutics
Anthony D. Keefe et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Strategies in the design of nanoparticles for therapeutic applications
Robby A. Petros et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Spatiotemporal controlled delivery of nanoparticles to injured vasculature
Juliana M. Chan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation
Weiping Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Understanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticals
Daniel Q. McNerny et al.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2010)
Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy
Ling-dong Quan et al.
ARTHRITIS RESEARCH & THERAPY (2010)
Development of HPMA copolymer-anticancer conjugates: Clinical experience and lessons learnt
Ruth Duncan
ADVANCED DRUG DELIVERY REVIEWS (2009)
Combination therapy: Opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines
Francesca Greco et al.
ADVANCED DRUG DELIVERY REVIEWS (2009)
Targeting Bone Metastases with a Bispecific Anticancer and Antiangiogenic Polymer-Alendronate-Taxane Conjugate
Keren Miller et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Protein C-Terminal Modification through Thioacid/Azide Amidation
Xiaohong Zhang et al.
BIOCONJUGATE CHEMISTRY (2009)
PAMAM-Triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity
Kun Ma et al.
BIOMATERIALS (2009)
Discontinued drugs in 2008: oncology drugs
Robert Williams
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer
Leonard W. Seymour et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2009)
Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: Implications for oral drug delivery
Deborah M. Sweet et al.
JOURNAL OF CONTROLLED RELEASE (2009)
Dependence of Pharmacokinetics and Biodistribution on Polymer Architecture: Effect of Cyclic versus Linear Polymers
Norased Nasongkla et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Expansile Nanoparticles: Synthesis, Characterization, and in Vivo Efficacy of an Acid-Responsive Polymeric Drug Delivery System
Aaron P. Griset et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection
J. Andrew MacKay et al.
NATURE MATERIALS (2009)
Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase
Angelo Fontana et al.
ADVANCED DRUG DELIVERY REVIEWS (2008)
In situ ATRP-Mediated hierarchical formation of giant amphiphile bionanoreactors
Benjamin Le Droumaguet et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Paclitaxel-initiated, controlled polymerization of lactide for the formulation of polymeric nanoparticulate delivery vehicles
Rong Tong et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Living ring-opening polymerization of a carbohydrate-derived lactone for the synthesis of protein-resistant biomaterials
Hiromitsu Urakami et al.
BIOMACROMOLECULES (2008)
Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer
L. Paz-Ares et al.
BRITISH JOURNAL OF CANCER (2008)
Methoxy polyethylene glycol-epoetin beta - A review of its use in the management of anaemia associated with chronic kidney disease
Monique P. Curran et al.
DRUGS (2008)
Temperature-regulated activity of responsive polymer-protein conjugates prepared by grafting-from via RAFT polymerization
Priyadarsi De et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting
Vaikunth Cuchelkar et al.
MOLECULAR PHARMACEUTICS (2008)
An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Ofra Benny et al.
NATURE BIOTECHNOLOGY (2008)
Nanoparticle therapeutics: an emerging treatment modality for cancer
Mark E. Davis et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters
Elena A. Dubikovskaya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mussel-inspired surface chemistry for multifunctional coatings
Haeshin Lee et al.
SCIENCE (2007)
Well-defined protein-polymer conjugates via in situ RAFT polymerization
Cyrille Boyer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Synthesis, characterization, and in vitro activity of dendrimer-streptokinase conjugates
Xiangtao Wang et al.
BIOCONJUGATE CHEMISTRY (2007)
In situ formation of protein-polymer conjugates through reversible addition fragmentation chain transfer polymerization
Jingquan Liu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
PLA/PLGA nanoparticles for sustained release of docetaxel
T. Musumeci et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)
Pharmacokinetics and pharmacodynamics of intravenous and subcutaneous Continuous Erythropoietin Receptor Activator (CERA) in patients with chronic kidney disease
Iain C. Macdougall et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli
Shawn DeFrees et al.
GLYCOBIOLOGY (2006)
N-terminal protein modification through a biomimetic transamination reaction
Joshua M. Gilmore et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Dendrimers as drugs: Discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention
Tom D. McCarthy et al.
MOLECULAR PHARMACEUTICS (2005)
Streptavidin as a macroinitiator for polymerization: In situ protein-polymer conjugate formation
D Bontempo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Poly(ethylene oxide sulfide): New poly(ethylene glycol) derivatives degradable in reductive conditions
Y Lee et al.
BIOMACROMOLECULES (2005)
Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
Y Matsumura et al.
BRITISH JOURNAL OF CANCER (2004)
Dendritic molecular capsules for hydrophobic compounds
MT Morgan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
P Caliceti et al.
ADVANCED DRUG DELIVERY REVIEWS (2003)
Pegaspargase: a review of clinical studies
ML Graham
ADVANCED DRUG DELIVERY REVIEWS (2003)
The dawning era of polymer therapeutics
R Duncan
NATURE REVIEWS DRUG DISCOVERY (2003)
A novel controlled release formulation for the anticancer drug paclitaxel (Taxol®):: PLGA nanoparticles containing vitamin E TPGS
L Mu et al.
JOURNAL OF CONTROLLED RELEASE (2003)
The further evolution of biotech
T Nagle et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Use of peginterferon a1fa-2a (40 KD) (Pegasys®) for the treatment of hepatitis C
KR Reddy et al.
ADVANCED DRUG DELIVERY REVIEWS (2002)
Chemistry for peptide and protein PEGylation
MJ Roberts et al.
ADVANCED DRUG DELIVERY REVIEWS (2002)
Enzymatic procedure for site-specific pegylation of proteins
H Sato
ADVANCED DRUG DELIVERY REVIEWS (2002)
Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications
YS Wang et al.
ADVANCED DRUG DELIVERY REVIEWS (2002)
Synthesis and characterization of poly(glycerol-succinic acid) dendrimers
MA Carnahan et al.
MACROMOLECULES (2001)
Expanding the genetic code of Escherichia coli
L Wang et al.
SCIENCE (2001)
Synthesis and characterization of polyether-ester dendrimers from glycerol and lactic acid
MA Carnahan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Tumor-targeted chemotherapy with SMANCS in Lipiodol for renal cell carcinoma: Longer survival with larger size tumors
K Tsuchiya et al.
UROLOGY (2000)