Journal
NATURE REVIEWS CLINICAL ONCOLOGY
Volume 16, Issue 5, Pages 281-295Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41571-019-0166-8
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- National Natural Science Foundation of China [31871345]
- Wuhan University
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In the past decade, the development of a genome-editing technology mediated by CRISPR has made genetic engineering easier than ever, both in vitro and in vivo. CRISPR systems have enabled important advances in cancer research by accelerating the development of study models or as a tool in genetic screening studies, including those aiming to discover and validate therapeutic targets. In this Review, we discuss these applications as well as new potential uses of CRISPR to assist in cancer detection or the development of anticancer therapies.
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