Journal
ACS NANO
Volume 10, Issue 10, Pages 9174-9182Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b04996
Keywords
metal-organic framework; enzyme immobilization; nerve agent catalysis; nanocarrier
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Funding
- DTRA [HDTRA-1-14-1-0014]
- MRSEC program of the National Science Foundation at the Materials Research Center of Northwestern University [DMR-1121262]
- NU Office for Research
- MRSEC program at the Materials Research Center [NSF DMR-1121262]
- International Institute for Nanotechnology (IIN)
- State of Illinois, through the IIN
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We report the synthesis and characterization of a water-stable zirconium metal organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU 1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.
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