Journal
NATURE METHODS
Volume 15, Issue 12, Pages 1021-1028Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-018-0222-9
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Funding
- National Institutes of Health [R01 HD086325, R01 AI120560, R33CA223908]
- National Science Foundation [ECCS-1807601]
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Acoustic tweezers are a versatile set of tools that use sound waves to manipulate bioparticles ranging from nanometer-sized extracellular vesicles to millimeter-sized multicellular organisms. Over the past several decades, the capabilities of acoustic tweezers have expanded from simplistic particle trapping to precise rotation and translation of cells and organisms in three dimensions. Recent advances have led to reconfigured acoustic tweezers that are capable of separating, enriching, and patterning bioparticles in complex solutions. Here, we review the history and fundamentals of acoustic-tweezer technology and summarize recent breakthroughs.
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