4.8 Article

U-Net: deep learning for cell counting, detection, and morphometry

Journal

NATURE METHODS
Volume 16, Issue 1, Pages 67-+

Publisher

NATURE RESEARCH
DOI: 10.1038/s41592-018-0261-2

Keywords

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Funding

  1. German Federal Ministry for Education and Research (BMBF) through the MICROSYSTEMS project [0316185B]
  2. Federal Ministry for Economic Affairs and Energy [ZF4184101CR5]
  3. Deutsche Forschungsgemeinschaft (DFG) through the collaborative research center KIDGEM [SFB 1140, SFB 746, INST 39/839, INST 39/840, INST 39/841]
  4. Bernstein Award 2012 [01GQ2301]
  5. Clusters of Excellence BIOSS [EXC 294]
  6. BrainLinks-Brain-Tools [EXC 1086]
  7. Swiss National Science Foundation (SNF) [173880]
  8. ERC Starting grant OptoMotorPath [338041]
  9. FENS-Kavli Network of Excellence (FKNE)
  10. [DI 1908/3-1]
  11. [DI 1908/6-1]
  12. [DI 1908/7-1]

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U-Net is a generic deep-learning solution for frequently occurring quantification tasks such as cell detection and shape measurements in biomedical image data. We present an ImageJ plugin that enables non-machine-learning experts to analyze their data with U-Net on either a local computer or a remote server/cloud service. The plugin comes with pretrained models for single-cell segmentation and allows for U-Net to be adapted to new tasks on the basis of a few annotated samples.

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