Journal
NATURE METHODS
Volume 15, Issue 12, Pages 1037-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-018-0183-z
Keywords
-
Categories
Funding
- Wellcome Trust
- EMBO
- ERC [AdG 695709]
- BBSRC [BB/N009835]
- Faculty of Engineering at University College London
- Medical Research Council (MRC)
- MRC
- European Commission [328048]
- BBSRC [BB/N009835/1] Funding Source: UKRI
Ask authors/readers for more resources
Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity 'on the fly' during behavior.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available