Journal
NATURE METHODS
Volume 16, Issue 2, Pages 167-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-018-0301-y
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Funding
- DARPA [W911NF-15-2-0065]
- NIH [1DP5OD009172, 5R01AI132403, 1R01DK118044]
- NSF [MCB-1453219]
- ONR [N00014-15-1-2704]
- Burroughs Wellcome PATH [1016691]
- Junior Fellowship of the Simons Society of Fellows [527896]
- NIDDK F30 fellowship [F30 DK111145-01A1]
- NIH MSTP training grant [NIH T32GM007367]
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Engineering of microbial communities in open environments remains challenging. Here we describe a platform used to identify and modify genetically tractable mammalian microbiota by engineering community-wide horizontal gene transfer events in situ. With this approach, we demonstrate that diverse taxa in the mouse gut microbiome can be modified directly with a desired genetic payload. In situ microbiome engineering in living animals allows novel capabilities to be introduced into established communities in their native milieu.
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