Journal
NATURE MEDICINE
Volume 24, Issue 12, Pages 1795-1803Publisher
NATURE RESEARCH
DOI: 10.1038/s41591-018-0271-8
Keywords
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Funding
- K22 Transition Career Development Award through the National Cancer Institute (NCI)
- Concern Foundation
- V Foundation for Cancer Research
- NIH (National Institutes of Health)
- INSERM (Institut National de la Sante et la Recherche Medicale, France)
- KAUST (King Abdullah University of Science and Technology, Saudi Arabia)
- NATIONAL CANCER INSTITUTE [K22CA212045] Funding Source: NIH RePORTER
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The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
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