Journal
NATURE IMMUNOLOGY
Volume 20, Issue 2, Pages 121-128Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-018-0304-y
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Funding
- Wellcome Trust Investigator Award [099266/Z/12/Z]
- Wellcome Trust [099266/Z/12/Z] Funding Source: Wellcome Trust
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gamma delta T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the gamma delta T cell antigen receptor. Here we discuss the inherent challenges in answering this question, the new opportunities provided by recent studies, and the criteria by which the field might judge success.
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