4.7 Editorial Material

Targeting fibrin in neurodegeneration

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NATURE IMMUNOLOGY
Volume 19, Issue 11, Pages 1149-1150

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NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-018-0241-9

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Deposition of fibrin in the brain and central nervous system occurs after injury or disease. This process unmasks a conserved cryptic epitope of fibrin that activates microglia; blocking this interaction can limit inflammation and neurotoxicity.

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