Journal
NATURE GENETICS
Volume 51, Issue 1, Pages 51-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41588-018-0303-9
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Funding
- British Heart Foundation [FS/12/82/29736] Funding Source: Medline
- Medical Research Council [MC_UU_00007/10, MR/L01341X/1, MR/N01104X/2, MC_UU_12015/1, G1001799, MR/N01104X/1, G9815508, MR/S003886/1, MR/S003746/1, MC_PC_15018, MR/M004422/1] Funding Source: Medline
- NCI NIH HHS [P30 CA068485, T32 CA160056] Funding Source: Medline
- NCRR NIH HHS [S10 RR025141] Funding Source: Medline
- NEI NIH HHS [P30 EY008126] Funding Source: Medline
- NHGRI NIH HHS [T32 HG008341] Funding Source: Medline
- NHLBI NIH HHS [R01 HL133786, R01 HL105756, U01 HL120393, R21 HL121429, R01 HL113933, R01 HL120393, U19 HL065962, U01 HL130114, R01 HL124262] Funding Source: Medline
- NIAMS NIH HHS [K23 AR064768] Funding Source: Medline
- NIA NIH HHS [P30 AG010129, U01 AG052409] Funding Source: Medline
- NICHD NIH HHS [K12 HD043483] Funding Source: Medline
- NIDDK NIH HHS [P30 DK020572, U01 DK062370, R01 DK076077, R01 DK087635, R01 DK105821, DP3 DK108220, K01 DK109019] Funding Source: Medline
- NIGMS NIH HHS [P50 GM115305] Funding Source: Medline
- NIH HHS [S10 OD023680] Funding Source: Medline
- NINDS NIH HHS [R01 NS017950, UH3 NS100605] Funding Source: Medline
- BLRD VA [I01 BX003340, I01 BX003362, I01 BX003360] Funding Source: Medline
- CSRD VA [I01 CX000982, I01 CX001897, I01 CX000570] Funding Source: Medline
- ESRC [ES/S008349/1] Funding Source: UKRI
- MRC [MR/S003746/1, MR/L01341X/1, MR/S003886/1, G1001799, MC_UU_12015/1, MR/M004422/1, UKDRI-5001, MR/N01104X/1, MR/N01104X/2, MC_UU_00007/10] Funding Source: UKRI
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K12HD043483] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [P30CA068485, T32CA160056] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [P30EY008126] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL113933, R01HL133786, U01HL130114, R01HL124262, R01HL105756] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [T32HG008341] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK020572, U01DK062370, R01DK105821, K01DK109019, R01DK076077, R01DK087635] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM115305] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS017950, UH3NS100605] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG052409, ZIAAG000675] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [S10OD023680] Funding Source: NIH RePORTER
- Veterans Affairs [I01BX003340, I01BX003360, I01CX000982, I01BX003362] Funding Source: NIH RePORTER
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In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
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