Journal
NATURE CELL BIOLOGY
Volume 21, Issue 2, Pages 152-161Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0258-1
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Funding
- NIH [5 T32 GM095450-04]
- Ford Foundation Fellowship
- NIH DP2 New Innovator Award [1DP2CA195762-01]
- American Cancer Society Research Scholar Award [RSG-14-051-01-DMC]
- Pew-Stewart Scholars in Cancer Research Grant
- Alex's Lemonade Stand Foundation 'A' Award
- Howard Hughes Medical Institute Gilliam Fellowship Program
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Research over the past several decades has unmasked a major contribution of disrupted chromatin regulatory processes to human disease, particularly cancer. Advances in genome-wide technologies have highlighted frequent mutations in genes encoding chromatin-associated proteins, identified unexpected synthetic lethal opportunities and enabled increasingly comprehensive structural and functional dissection. Here, we review recent progress in our understanding of oncogenic mechanisms at each level of chromatin organization and regulation, and discuss new strategies towards therapeutic intervention.
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