Journal
NATURE CELL BIOLOGY
Volume 21, Issue 1, Pages 25-31Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0234-9
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Funding
- ERC
- Munich Heart Alliance (DZHK)
- Max Planck Society
- Deutsche Forschungsgesellschaft [SFB-863]
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Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework.
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