4.8 Review

Metabolism as a guiding force for immunity

Related references

Note: Only part of the references are listed.
Editorial Material Oncology

Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants

Semanti Mukherjee et al.

Summary: In this study, Wang et al. used whole-genome sequencing to comprehensively analyze common and rare variants associated with lung cancer risk in individuals with East Asian ancestry. Their findings suggest that rare promoter variants in the BRCA2 gene are associated with an increased risk of lung cancer.

CANCER CELL (2022)

Article Immunology

Newly Generated CD4+ T Cells Acquire Metabolic Quiescence after Thymic Egress

Shusong Zhang et al.

JOURNAL OF IMMUNOLOGY (2018)

Review Biotechnology & Applied Microbiology

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

Maurizio Battino et al.

BIOTECHNOLOGY ADVANCES (2018)

Article Cell Biology

CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

Shilpak Chatterjee et al.

CELL METABOLISM (2018)

Article Cell Biology

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

Ajit S. Divakaruni et al.

CELL METABOLISM (2018)

Review Immunology

Human T Cell Development, Localization, and Function throughout Life

Brahma V. Kumar et al.

IMMUNITY (2018)

Article Multidisciplinary Sciences

Hexokinase II may be dispensable for CD4 T cell responses against a virus infection

Siva Karthik Varanasi et al.

PLOS ONE (2018)

Article Multidisciplinary Sciences

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Michael D. Kornberg et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Roisin M. Loftus et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills et al.

NATURE (2018)

Article Multidisciplinary Sciences

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhenyu Zhong et al.

NATURE (2018)

Review Immunology

Unraveling the Complex Interplay Between T Cell Metabolism and Function

Ramon I. Klein Geltink et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

Article Oncology

Hexokinase 2 is dispensable for T cell-dependent immunity

Manan M. Mehta et al.

CANCER & METABOLISM (2018)

Article Immunology

Glutathione Primes T Cell Metabolism for Inflammation

Tak W. Mak et al.

IMMUNITY (2017)

Article Multidisciplinary Sciences

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

Alejandra Mendoza et al.

NATURE (2017)

Article Multidisciplinary Sciences

Metabolic origins of spatial organization in the tumor microenvironment

Carlos Carmona-Fontaine et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1

Nanhai He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

W. K. Eddie Ip et al.

SCIENCE (2017)

Article Biochemistry & Molecular Biology

Mitochondrial Priming by CD28

Ramon I. Klein Geltink et al.

Article Biochemistry & Molecular Biology

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Eric V. Dang et al.

Article Biochemistry & Molecular Biology

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

Tyler K. Ulland et al.

Review Cell Biology

Ancillary Activity: Beyond Core Metabolism in Immune Cells

Daniel J. Puleston et al.

CELL METABOLISM (2017)

Review Biochemistry & Molecular Biology

Metabolic Instruction of Immunity

Michael D. Buck et al.

Article Medicine, Research & Experimental

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity

Duncan Howie et al.

JCI INSIGHT (2017)

Article Cell Biology

Serine Is an Essential Metabolite for Effector T Cell Expansion

Eric H. Ma et al.

CELL METABOLISM (2017)

Review Immunology

Immunometabolism governs dendritic cell and macrophage function

Luke A. J. O'Neill et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Article Immunology

Amino acid auxotrophy as a system of immunological control nodes

Peter J. Murray

NATURE IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Michael D. Buck et al.

Article Biochemistry & Molecular Biology

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

Andrea J. Wolf et al.

Article Biochemistry & Molecular Biology

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Roger Geiger et al.

Review Cell Biology

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

Harding H. Luan et al.

CELL METABOLISM (2016)

Article Cell Biology

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

Mathias Wenes et al.

CELL METABOLISM (2016)

Article Biochemistry & Molecular Biology

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Thekla Cordes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

Katherine C. Verbist et al.

NATURE (2016)

Article Multidisciplinary Sciences

Normalizing the environment recapitulates adult human immune traits in laboratory mice

Lalit K. Beura et al.

NATURE (2016)

Article Multidisciplinary Sciences

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

Petros A. Tyrakis et al.

NATURE (2016)

Letter Immunology

Fatty acid oxidation in macrophage polarization

Mitsunori Nomura et al.

NATURE IMMUNOLOGY (2016)

Article Immunology

C13orf31 (FAMIN) is a central regulator of immunometabolic function

M. Zaeem Cader et al.

NATURE IMMUNOLOGY (2016)

Review Immunology

Integrating immunometabolism and macrophage diversity

Maxim N. Artyomov et al.

SEMINARS IN IMMUNOLOGY (2016)

Review Immunology

Inflammasomes: mechanism of assembly, regulation and signalling

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

Chao Wang et al.

Article Biochemistry & Molecular Biology

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ping-Chih Ho et al.

Article Biochemistry & Molecular Biology

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

Guoliang Cui et al.

Article Biochemistry & Molecular Biology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih-Hao Chang et al.

Review Immunology

T cell metabolism drives immunity

Michael D. Buck et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Review Immunology

Metabolic control of regulatory T cell development and function

Hu Zeng et al.

TRENDS IN IMMUNOLOGY (2015)

Review Immunology

Transcriptional Control of Early T and B Cell Developmental Choices

Ellen V. Rothenberg

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Article Immunology

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

Emmanuel L. Gautier et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Article Immunology

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

Raymond P. Donnelly et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Oncology

The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology

Lisa Heitmann et al.

JOURNAL OF PATHOLOGY (2014)

Article Multidisciplinary Sciences

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Luciana Berod et al.

NATURE MEDICINE (2014)

Article Multidisciplinary Sciences

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas

Maria A. Duque-Correa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity

Shih-Chin Cheng et al.

SCIENCE (2014)

Article Biochemistry & Molecular Biology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

Chih-Hao Chang et al.

Review Immunology

Tissue-resident macrophages

Luke C. Davies et al.

NATURE IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

E. L. Pearce et al.

SCIENCE (2013)

Review Immunology

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

David H. Munn et al.

TRENDS IN IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

The TSC-mTOR pathway regulates macrophage polarization

Vanessa Byles et al.

NATURE COMMUNICATIONS (2013)

Review Immunology

T cell receptor signalling networks: branched, diversified and bounded

Rebecca J. Brownlie et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

Eszter Molnar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

Review Immunology

Protective and pathogenic functions of macrophage subsets

Peter J. Murray et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Immunology

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

Juan-Carlos Rodriguez-Prados et al.

JOURNAL OF IMMUNOLOGY (2010)

Review Multidisciplinary Sciences

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

John J. O'Shea et al.

SCIENCE (2010)

Article Cell Biology

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

Divya Vats et al.

CELL METABOLISM (2006)

Article Biochemistry & Molecular Biology

HIF-1α is essential for myeloid cell-mediated inflammation

T Cramer et al.

Article Immunology

The CD28 signaling pathway regulates glucose metabolism

KA Frauwirth et al.

IMMUNITY (2002)

Review Immunology

Nitric oxide and the immune response

C Bogdan

NATURE IMMUNOLOGY (2001)