Journal
NATURE CELL BIOLOGY
Volume 21, Issue 2, Pages 143-151Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0242-9
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Funding
- European Research Council (ERC) [616434]
- Spanish Ministry of Economy and Competitiveness [BFU2017-89488-P, SEV-2012-0208]
- AXA Research Fund
- Bettencourt Schueller Foundation
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) [SGR-831]
- EMBL-CRG Systems Biology Program
- CERCA Program/Generalitat de Catalunya
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Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology.
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