Journal
NATURE
Volume 563, Issue 7732, Pages 501-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41586-018-0692-z
Keywords
-
Categories
Funding
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [U19AI110818]
- USDA [2017-05741]
- NIH Intramural Research Program
- National Library of Medicine
- National Human Genome Research Institute
- NSF [PHY-1427654]
- NIH [R01AI101112, R35GM118336, R21AI121853, R01AI123338, T32GM007739, NIH/NCATS UL1TR000043, DP2OD008540, U01AI088647, 1R01AI121211, D43TW001130-08, U01HL130010, UM1HG009375, 5K22AI113060, 1R21AI123937, R00DC012069]
- Defence Advanced Research Project Agency [HR0011-17-2-0047]
- Jane Coffin Childs Memorial Fund
- Center for Theoretical Biological Physics postdoctoral fellowship
- Robertson Foundation
- McNair Foundation
- Welch Foundation [Q-1866]
- French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases [ANR-10-LABX-62-IBEID]
- Agence Nationale de la Recherche [ANR-17-ERC2-0016-01]
- European Union [734584]
- Pew and Searle Scholars Programs
- Klingenstein-Simons Fellowship in the Neurosciences
- Verily Life Sciences
- BBSRC [BB/F021933/1, BB/M001512/1] Funding Source: UKRI
- MRC [MC_PC_16052, MC_PC_16078, 1981052] Funding Source: UKRI
Ask authors/readers for more resources
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available