Journal
ACS NANO
Volume 10, Issue 4, Pages 4421-4430Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b00053
Keywords
gold nanoparticles; protein corona; macrophages; complement system; surface functionality
Categories
Funding
- NIH [GM GM077173]
- Center for Hierarchical Manufacturing [CMMI-1025020]
- Saramadan Elmi federation [11/66332]
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Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages.
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