Journal
ACS NANO
Volume 10, Issue 11, Pages 10186-10194Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b05502
Keywords
synthetic melanin; MRI; magnetometry; polymerization; antiferromagnetic coupling
Categories
Funding
- AFOSR [FA9550-11-1-0105]
- Department of Chemistry and Biochemistry at UC San Diego
- Compagnia di San Paolo
- State Key Laboratory of Polymer Materials Engineering, Sichuan University [sklpme2016-3-03]
- National Institute of Biomedical Imaging and Bioengineering of NIH [F32EB021859]
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We describe a synthetic method for increasing and controlling the iron loading of synthetic melanin nanoparticles and use the resulting materials to perform a systematic quantitative investigation on their structure property relationship. A comprehensive analysis by magnetometry, electron paramagnetic resonance, and nuclear magnetic relaxation dispersion reveals the complexities of their magnetic behavior and how these intraparticle magnetic interactions manifest in useful material properties such as their performance as MRI contrast agents. This analysis allows predictions of the optimal iron loading through a quantitative modeling of antiferromagnetic coupling that arises from proximal iron ions. This study provides a detailed understanding of this complex class of synthetic biomaterials and gives insight into interactions and structures prevalent in naturally occurring melanins.
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