Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1848, Issue 10, Pages 2603-2620Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2014.10.036
Keywords
Calcium channel; Caveola; Chloride channel; EGFR; Lipid raft; Potassium channel
Categories
Funding
- University of Tours
- Region Centre
- INSERM
- Ligue Contre le Cancer
- Canceropole Grand Ouest
- Tours' Hospital Oncology Association ACORT
- CANCEN
- Ministere de l'Enseignement Superieur et de la Recherche
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Membrane lipid rafts are distinct plasma membrane nanodomains that are enriched with cholesterol, sphingolipids and gangliosides, with occasional presence of saturated fatty acids and phospholipids containing saturated acyl chains. It is well known that they organize receptors (such as Epithelial Growth Factor Receptor), ion channels and their downstream acting molecules to regulate intracellular signaling pathways. Among them are Ca2+ signaling pathways, which are modified in tumor cells and inhibited upon membrane raft disruption. In addition to protein components, lipids from rafts also contribute to the organization and function of Ca2+ signaling microdomains. This article aims to focus on the lipid raft KCa/CICa/Ca2+ channel complexes that regulate Ca2+ and EGFR signaling in cancer cells, and discusses the potential modification of these complexes by lipids as a novel therapeutic approach in tumor development. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers. (C) 2014 Elsevier B.V. All rights reserved.
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