Journal
NATURAL PRODUCT RESEARCH
Volume 34, Issue 5, Pages 646-650Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1492576
Keywords
Alzheimer's disease; Tau protein; Lichens
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Funding
- Fondecyt Regular [1150745]
- INACH [RT 13-13, MT 03-14]
- Fondo Nacional de Desarrollo Cientifico and Tecnologico
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Alzheimer's disease (AD) is the most common form of dementia involving A beta and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders named as tauopathies. Here, we have isolated seventeen compounds belonging to six lichens species. Due to scarce of spectroscopic data of the compound 5,7-dihydroxy-6-methylphthalide, we explained their structural elucidation based on NMR data. In this study, we show that only tenuiorin from Umbilicaria antarctica inhibited 50% of tau 4R at 100 mu M. Then, we shown that molecular interactions of tenuiorin with the steric zipper model of the hexapeptide (306)VQIVYK(311) were studied by docking calculations and the results suggested that tenuiorin forms both hydrogen bonds with lysine and glutamine side chains and forms several hydrophobic interactions with valine and lysine from (306)VQIVYK(311) motif. [GRAPHICS] .
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