Journal
NATURAL PRODUCT RESEARCH
Volume 34, Issue 4, Pages 553-557Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1489387
Keywords
Hypochaeris radicata; phytochemicals; urease inhibition; Carbonic cnhydrase inhibition
Categories
Ask authors/readers for more resources
Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds (1-4). On evaluation, compounds (1-4) exhibited selective activity against urease enzyme with an IC50 value of 180.11 +/- 2.00, 27.18 +/- 0.80, 24.12 +/- 0.2 and 30.12 +/- 1.10 mu M respectively. The compounds (1-4) were found to be inactive against carbonic anhydrase enzyme. Thiourea was used as standard inhibitor (21 +/- 0.14 mu M) of urease enzyme.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available