Journal
NATURAL PRODUCT RESEARCH
Volume 34, Issue 3, Pages 378-384Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1534105
Keywords
marine-derived fungus; Penicillium janthinellum; prenylated indole alkaloid; paraherquamide
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Funding
- National Natural Science Foundation of China [81703411, U1606403]
- major project for the Natural Science Foundation of the Jiangsu Higher Education Institutions of China [17KJA350005]
- Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology [2016ASKJ08]
- Taishan Scholars Program, China
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A new prenylated indole alkaloid, named paraherquamide J (1), together with four known compounds (2-5), were isolated from the mangrove rhizosphere soil-derived fungus Penicillium janthinellum HK1-6. The planar structure and relative configuration of 1 were determined by detailed analysis of the spectroscopic data especially the NOESY spectrum. The absolute configuration of 1 was determined by ECD spectra. Compound 2 was first isolated as a natural product and named as paraherquamide K. All isolated metabolites were evaluated for their antibacterial, topoisomerase I (topo I) inhibitory activities and lethality towards brine shrimp Artemia salina.
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