Journal
NATURAL PRODUCT RESEARCH
Volume 34, Issue 22, Pages 3267-3274Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1557173
Keywords
Apoptosis; breast cancer; cell cycle arrest; NMR; procyanidin C1
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Albezia odoratissima has many health benefits. The present study investigated the isolation, characterization and anticancer activity of procyanidin C1 from A. odoratissima bark. Procyanidin C1 was isolated and characterized by IR, C-13 NMR, H-1 NMR and LC-MS spectroscopic studies. Anticancer property of procyanidin C1 was explored by studying the expression of checkpoint kinases, Bcl-2 and BAX, cell cycle, DNA damage and caspase 3 and 9 levels. Procyanidin C1 exhibited significant cytotoxicity against TNBC (MDA-MB- 231), hormone positive (MCF-7) cell lines. Its IC50 value is comparable to tamoxifen towards MDA-MB- 231 cell line, but considerably higher towards MCF-7 cell line. Procyanidin C1 induced DNA damage, cell cycle arrest and enhanced the expression of checkpoint kinases. Procyanidin C1 decreased the level of Bcl-2 but increased the BAX, caspase 3 and 9 expression in cancer cells. This study indicates the antiproliferative property of procyanidin C1 against breast cancer cells by inducing apoptosis.
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