4.4 Article

A new nucleoside and two new pyrrole alkaloid derivatives from Cordyceps militaris

Journal

NATURAL PRODUCT RESEARCH
Volume 34, Issue 3, Pages 341-350

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1531861

Keywords

Cordyceps militaris; nucleoside; pyrrole alkaloid; anti-inflammatory activity

Funding

  1. key Project of National 863 Plan of the 12th Five-year Plan [2012AA021703]
  2. Project of Science and Technology Commission of Shanghai Municipality [13401901300]

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A new nucleoside, a new natural product nucleoside, and two new pyrrole alkaloids derivatives with eight known compounds were isolated from the fruiting body of Cordyceps militaris. The structures of the new compounds were elucidated through extensive analysis of spectroscopic data including 1D and 2D NMR, HRESIMS, IR and UV. All the isolated compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Unfortunately, all the isolates have shown no obvious activity.

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