New bisbibenzyl and phenanthrene derivatives fromDendrobium scabrilingueand their α-glucosidase inhibitory activity

Phytochemical investigation of the whole plant ofDendrobium scabrilingueresulted in the isolation of two new compounds namely dendroscabrols A (1) and B (2), along with eight known compounds (3-10). The structures of these compounds were determined by NMR and HR-ESI-MS experiments. All of the isolates were evaluated for their alpha-glucosidase inhibitory effect. Dendroscabrol B (2) and RF-3192C (10) showed the most potent alpha-glucosidase inhibitory activity. Dendroscabrol A (1), gigantol (5), coelonin (7) and lusianthridin (9) also exhibited strong activity as compared with the positive control acarbose. [GRAPHICS] .