4.6 Article

Development of a novel thermal-sensitive multifunctional liposome with antibody conjugation to target EGFR-expressing tumors

Journal

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 15, Issue 1, Pages 285-294

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.10.006

Keywords

EGFR; TSML; Doxorubicin; Erbitux; AuNR@MnMEIO; MRI

Funding

  1. Ministry of Science and Technology [MOST 106-2113-M-009-023, MOST 105-2923-M-009-002-MY2, MOHW 105-TDU-B-212-134005]
  2. Ministry of Health and Welfare of the Republic of China [MOST 106-2113-M-009-023, MOST 105-2923-M-009-002-MY2, MOHW 105-TDU-B-212-134005]
  3. Center For Intelligent Drug Systems and Smart Bio-devices (IDS2B) from The Featured Areas Research Center Program of the Ministry of Education (MOE) in Taiwan, Republic of China

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A novel EGFR-targeting, thermal-sensitive multifunctional liposome (TSML) was developed based on manganese-doped magnetismengineered iron oxide nanoparticles (MnMEIOs) and gold nanorods (AuNRs) for efficient photothermal therapy and magnetic resonance (MR) imaging. An Erbitux-conjugated TSML (Erb-TSML) was encapsulated with doxorubicin and gold nanorods conjugated with manganese-doped magnetism-engineered iron oxide nanoparticles, for theranostic applications of EGFR-positive tumors. The Erb-TSML selectively targeted EGFRpositive tumors and promoted tumor destruction by laser activation. Using confocal microscopy, MR and optical imaging, we demonstrated that Erb-TSML specifically bound to A431 tumor cells. No signs of major morphological damages to the normal tissues were observed in mice treated with Erb-TSMLand laser, indicating this theranostic platform protected heart against doxorubicin-induced toxicity to normal tissues. These results indicate that the Erb-TSML may be a promising diagnostic and therapeutic platform for EGFR-overexpressing tumors. (C) 2018 Elsevier Inc. All rights reserved.

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