Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 15, Issue 1, Pages 153-163Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.09.012
Keywords
Self-shielded property; Pt (IV) prodrug; Glycyrrhetinic acid; Liver targeting
Funding
- National Natural Science Foundation of China [51433004, 51773096]
- Natural Science Foundation of Tianjin [17JCZDJC33500]
- PCSIRT [IRT1257]
- Science and technology fund of Tianjin health and Family Planning Commission [2015KG111]
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The clinical translation remains a major challenge for platinumdrug loaded nanoparticle due to the complexity of composition and preparation. Here we employed only three ingredients to prepare Pt (IV) prodrug-loaded ligand-induced self-assembled nanoparticles (GA-ALG@Pt NPs) via facile one-pot route for liver tumor treatment. GA-ALG@Pt NPs were found equipped with intelligently ligand self-shielded property in which the internal GA could be induced to expose by initial cellular recognition, resulting in strengthened cellular uptake (20%-30%) and prolonged blood circulation time (3.43 times). Appreciable tumor targeting ability (2 times) and especially tumor selectivity (2.5 times) were obtained.Glutathione-triggered release of therapeutic agent generated satisfactory antitumor effect. Bio-safety is also a distinguishing feature of GA-ALG@ Pt NPs that greatly relief the nephrotoxicity and systematic toxicity of cisplatin. This conveniently synthesized nanoparticle processes superior targeting capacity and biosecurity, supplying an effective approach to translational cancer therapy in the future. (C) 2018 Elsevier Inc. All rights reserved.
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