Journal
NANOMEDICINE
Volume 13, Issue 22, Pages 2881-2899Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2018-0099
Keywords
andro-loaded MSNs; antibacteria; biocompatibility; electrospinning; histological analysis; hydrophilicity; prolonged antibacterial function; sustained release; wound dressing
Funding
- National Science Foundation of China [21676083, 81802178]
- Shanghai Lianmeng Gant [LM201603]
- Opening project of Shanghai Key Laboratory of Orthopedic Implant [KFKT2018001]
- Biomedical Engineering Crossover Project of Shanghai Jiao Tong University [YG2014ZD01]
- China Postdoctoral Science Foundation [2015M571574]
- Science and Technology Commission of Shanghai Municipality [18441902700]
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Aim: To assess the wound-healing ability of poly(lactic-co-glycolic acid) (PLGA) nanofibrous wound dressing incorporated with andrographolide (Andro)-loaded mesoporous silica nanoparticles (MSNs). Materials & methods: PLGA/Andro-MSNs nanofibrous membrane wound dressings were produced by electrospinning. The effects of MSNs on the hydrophilicity, degradation and mechanical strength of membranes were evaluated. The cumulative release of Andro in vitro was obtained. Cell culture and in vivo tests on infectious models were carried out. Results: The PLGA/Andro-MSNs membrane showed a sustained release of Andro. The incorporation of MSNs into PLGA improved the hydrophilicity of the nanofibrous membranes. Cell culture and in vivo tests showed that PLGA/Andro-MSNs membrane can promote epidermal cell adhesion and reduce inflammation process. Conclusion: PLGA/Andro-MSNs nanofibrous membrane exhibited an efficient wound-healing ability. [GRAPHICS] .
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