Journal
NANO LETTERS
Volume 19, Issue 2, Pages 1210-1215Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.8b04715
Keywords
Solid-state nanopores; nanopore sensing; single-molecule; DNA storage; DNA nanotechnology
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Funding
- ERC Consolidator Grant [647144]
- Cambridge Trust
- India Inc.
- EPSRC [EP/M008258/1]
- Trinity Hall, Cambridge, United Kingdom
- EPSRC [EP/M008258/1] Funding Source: UKRI
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Solid-state nanopores are powerful tools for reading the three-dimensional shape of molecules, allowing for the translation of molecular structure information into electric signals. Here, we show a high-resolution integrated nanopore system for identifying DNA nanostructures that has the capability of distinguishing attached short DNA hairpins with only a stem length difference of 8 bp along a DNA double strand named the DNA carrier. Using our platform, we can read up to 112 DNA hairpins with a separating distance of 114 bp attached on a DNA carrier that carries digital information. Our encoding strategy allows for the creation of a library of molecules with a size of up to 5 x 10(33) (2(112)) that is only built from a few hundred types of base molecules for data storage and has the potential to be extended by linking multiple DNA carriers. Our platform provides a nanopore- and DNA nanostructure-based data storage method with convenient access and the potential for miniature-scale integration.
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