Journal
NANO LETTERS
Volume 18, Issue 11, Pages 6778-6788Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.8b02639
Keywords
Bismuth nanoraspberry; multimodal imaging; drug delivery; chemo-photothermal therapy; theranostics
Categories
Funding
- National Natural Science Foundation of China [21473045, 51772066, 51573096, 31771036]
- Fundamental Research Funds from the Central University [PIRS OF HIT A201503]
- Natural Science Foundation of Heilongjiang Province, China [E2015003]
- State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology [2018DX04]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20160422091238319]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
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Development of stimuli-responsive theranostics is of great importance for precise cancer diagnosis and treatment. Herein, bovine serum albumin (BSA) modified bismuth nanoraspberries (Bi-BSA NRs) are developed as cancer theranostic agents for multimodal imaging and chemo-photothermal combination therapy. The Bi-BSA NRs are synthesized in aqueous phase via a facile reduction method using Bi2O3 nanospheres as the sacrificial template. The morphology, biocompatibility, photothermal effect, drug loading/releasing abilities, chemotherapy effect, synergistic chemo-photothermal therapy efficacy, and multimodal imaging capacities of Bi-BSA NRs have been investigated. The results show that the NRs possess multiple unique features including (i) raspberry -like morphology with high specific surface area (similar to 52.24 m(2).g(-1)) and large cavity (total pore volume similar to 0.30 cm(3).g(-1)), promising high drug loading capacity (similar to 69 wt %); (ii) dual-stimuli responsive drug release, triggered by acidic pH and NIR laser irradiation; (iii) infrared thermal (IRT), photoacoustic (PA) and X-ray computed tomography (CT) trimodality imaging with the CT contrast enhanced efficiency as high as similar to 66.7 HU-mL-mg(-1) (iv) 100% tumor elimination through the combination chemo-photothermal therapy. Our work highlights the great potentials of Bi-BSA NRs as a versatile theranostics for multimodal imaging and combination therapy.
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