Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 25, Issue 3, Pages 306-324Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458518805246
Keywords
Multiple sclerosis; experimental autoimmune encephalomyelitis; animal models; zebrafish; demyelination
Categories
Funding
- NIHR Sheffield Biomedical Research Centre (BRC)
Ask authors/readers for more resources
y Multiple sclerosis (MS) is a chronic, immune-mediated demyelinating disease of the central nervous system. Animal models of MS have been critical for elucidating MS pathological mechanisms and how they may be targeted for therapeutic intervention. Here we review the most commonly used animal models of MS. Although these animal models cannot fully replicate the MS disease course, a number of models have been developed to recapitulate certain stages. Experimental autoimmune encephalomyelitis (EAE) has been used to explore neuroinflammatory mechanisms and toxin-induced demyelinating models to further our understanding of oligodendrocyte biology, demyelination and remyelination. Zebrafish models of MS are emerging as a useful research tool to validate potential therapeutic candidates due to their rapid development and amenability to genetic manipulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available