Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 25, Issue 9, Pages 1326-1328Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458518807059
Keywords
Multiple sclerosis; nutritional; vitamin D; intoxication; kidney failure
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Knowledge about complications of chronic ultra-high dose vitamin D supplementation is limited. We report a patient with primary progressive multiple sclerosis (MS) who presented with generalized weakness caused by hypercalcemia after uncontrolled intake of more than 50,000 IU of cholecalciferol per day over several months. Various treatment strategies were required to achieve normocalcemia. However, renal function improved only partly and further progression of MS was observed. We conclude that patients need to be informed about the risks of uncontrolled vitamin D intake and neurologists need to be alert of biochemical alterations and symptoms of vitamin D toxicity.
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