Journal
MOLECULES
Volume 24, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules24020374
Keywords
traditional Chinese medicine decoction; quality evaluation; UPLC-QTOF-MS; UFLC-QQQ-MS; ShenFu prescription decoction
Funding
- National Natural Science Foundation of China [81360663, 81703823]
- Natural Science Foundation of Jiangxi Province [20181BAB215039]
- Science and technology research project Technology Research Project of Jiangxi Education Department [GJJ170751, GJJ170753]
- Jiangxi science and technology program of TCM [2018A332]
- Jiangxi national traditional medicine modern technology National Traditional Medicine Modern Technology and Industry Development Cooperation Center Project [jxxt2017006]
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Decoction is one of the oldest forms of traditional Chinese medicine and it is widely used in clinical practice. However, the quality evaluation and control of traditional decoction is a challenge due to the characteristics of complicated constituents, water as solvent, and temporary preparation. ShenFu Prescription Decoction (SFPD) is a classical prescription for preventing and treating many types of cardiovascular disease. In this article, a comprehensive and rapid method for quality evaluation and control of SFPD was developed, via qualitative and quantitative analysis of the major components by integrating ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry and ultra-fast-performance liquid chromatography equipped with triple quadrupole mass spectrometry. Consequently, a total of 39 constituents were tentatively identified in qualitative analysis, of which 21 compounds were unambiguously confirmed by comparing with reference substances. We determined 13 important constituents within 7 min by multiple reaction monitoring. The validated method was applied for determining five different proportion SFPDs. It was found that different proportions generated great influence on the dissolution of constituents. This may be one of the mechanisms for which different proportions play different synergistic effects. Therefore, the developed method is a fast and useful approach for quality evaluation of SFPD.
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