Journal
MOLECULES
Volume 24, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules24020347
Keywords
keratinized tegument; amphibian skin peptides; wound healing; UV-irradiation protection; skin defenses; eco-physiology; animal physiology; Batracochytrium dendrobatidis
Funding
- Universita degli Studi di Genova trough FRA2017 funding
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Amphibian skin is not to be considered a mere tegument; it has a multitude of functions related to respiration, osmoregulation, and thermoregulation, thus allowing the individuals to survive and thrive in the terrestrial environment. Moreover, amphibian skin secretions are enriched with several peptides, which defend the skin from environmental and pathogenic insults and exert many other biological effects. In this work, the beneficial effects of amphibian skin peptides are reviewed, in particular their role in speeding up wound healing and in protection from oxidative stress and UV irradiation. A better understanding of why some species seem to resist several environmental insults can help to limit the ongoing amphibian decline through the development of appropriate strategies, particularly against pathologies such as viral and fungal infections.
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