Related references
Note: Only part of the references are listed.The recent progress of isoxazole in medicinal chemistry
Jie Zhu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2018)
Indolyl-isoxazolidines attenuate LPS-stimulated pro-inflammatory cytokines and increase survival in a mouse model of sepsis: Identification of potent lead
Gagandeep Singh et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Synthesis, Immunosuppressive Properties, and Mechanism of Action of a New Isoxazole Derivative
Marcin Maczynski et al.
MOLECULES (2018)
5-Amino-3-methyl-4-isoxazolecarboxylic acid hydrazide derivatives with in vitro immunomodulatory activities
Angelika Drynda et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2017)
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC
Heba A. H. Elshemy et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Isoxazole ring as a useful scaffold in a search for new therapeutic agents
Angelika Sysak et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Analgesic, anti-inflammatory, and antimicrobial activities of novel isoxazole/pyrimidine/pyrazole substituted benzimidazole analogs
Krishna Veni Chikkula et al.
MEDICINAL CHEMISTRY RESEARCH (2017)
The safety profile of parecoxib for the treatment of postoperative pain: a pooled analysis of 28 randomized, double-blind, placebo-controlled clinical trials and a review of over 10 years of postauthorization data
Stephan A. Schug et al.
JOURNAL OF PAIN RESEARCH (2017)
3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer
Kodagahalli Sathya Rakesh et al.
INFLAMMATION (2016)
1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology
Yoshikazu Uto
CURRENT PHARMACEUTICAL DESIGN (2016)
Medicinal Chemistry Perspective of Fused Isoxazole Derivatives
Mahesh A. Barmade et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)
Synthesis and biological evaluation of salicylic acid conjugated isoxazoline analogues on immune cell proliferation and angiogenesis
Naveen Puttaswamy et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)
Erden Banoglu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Influence of 5-amino-3-methyl-4-isoxazolecarbohydrazide on selective gene expression in Caco-2 cultured cells
Paulina Ploszaj et al.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2016)
Immunoregulatory effects of 4-(4-chlorophenyl)-1-(5-amino-3-methylisoxazole-4-carbonyl)-thiosemicarbazide (06K) in non-immunized and SRBC-immunized mice
Angelika Drynda et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2016)
Anti-inflammatory properties of an isoxazole derivative - MZO-2
Marcin Maczynski et al.
PHARMACOLOGICAL REPORTS (2016)
The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD
Kirsty E. Russell et al.
PLOS ONE (2016)
Comparative effectiveness of granulocyte colony-stimulating factors to prevent febrile neutropenia and related complications in cancer patients in clinical practice: A systematic review
Sarah Mitchell et al.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2016)
The effect of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on lymphocyte subsets and humoral immune response in SRBC-immunized mice
Angelika Drynda et al.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2015)
Discovery of a novel isoxazoline derivative of prednisolone endowed with a robust anti-inflammatory profile and suitable for topical pulmonary administration
E. Ghidini et al.
STEROIDS (2015)
Immune function in cyclophosphamide-treated mice is restored by the T-cell-tropic isoxazole derivative R-13
Michal Zimecki et al.
JOURNAL OF IMMUNOTOXICOLOGY (2015)
In vitro immunomodulatory effects of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide on the cellular immune response
Angelika Drynda et al.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2014)
Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies
Shravankumar Kankala et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Restoration of immune system function is accelerated in immunocompromised mice by the B-cell-tropic isoxazole R-11
Michal Zimecki et al.
PHARMACOLOGICAL REPORTS (2012)
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis
Virginie Andrzejak et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice
Lin Leng et al.
JOURNAL OF IMMUNOLOGY (2011)
Use of Filgrastim and Pegfilgrastim to Support Delivery of Chemotherapy Twenty Years of Clinical Experience
William Renwick et al.
BIODRUGS (2009)
Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine
Edwin Wagner et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027:: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models
Ivana Stojanovic et al.
CLINICAL IMMUNOLOGY (2007)
A potent immunomodulatory compound, (S,R)-3-phenyl-4,5-dihydro-5-isoxasole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice
Stanislava Stosic-Grujicic et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events - Meta-analysis of randomized trials
Jingjing Zhang et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
A 771726, the active metabolite of leflunomide, inhibits TNF-α and IL-1 from Kupffer cells
HW Yao et al.
INFLAMMATION (2004)
Structure/activity investigations of 5-substituted 3-methylisoxazole[5,4-d]1,2,3-triazin-4-one derivatives
A Jezierska et al.
ARCHIV DER PHARMAZIE (2004)
In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent leflunomide to its active α-cyanoenol metabolite A771726:: Mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes
AS Kalgutkar et al.
DRUG METABOLISM AND DISPOSITION (2003)
Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
ML Herrmann et al.
IMMUNOPHARMACOLOGY (2000)