4.6 Review

Chiral Derivatives of Xanthones with Antimicrobial Activity

Journal

MOLECULES
Volume 24, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/molecules24020314

Keywords

antimicrobial; xanthones; chirality; chiral derivatives of xanthones; caged xanthones

Funding

  1. Fundacao da Ciencia e Tecnologia (FCT/MCTES, PIDDAC) [PTDC/MAR-BIO/4694/2014, PTDC/AAG-TEC/0739/2014]
  2. European Regional Development Fund (ERDF) through the COMPETE-Programa Operacional Factores de Competitividade (POFC) programme [POCI-01-0145-FEDER-016790, POCI-01-0145-FEDER-016793]
  3. Reforcar a Investigacao, o Desenvolvimento Tecnologico e a Inovacao (RIDTI) [3599, 9471]
  4. COMPETE 2020, Portugal 2020 [POCI-01-0145-FEDER-028736]
  5. European Union through the ERDF
  6. FCT
  7. CHIRALXANT-CESPU-2018
  8. Fundação para a Ciência e a Tecnologia [PTDC/AAG-TEC/0739/2014, PTDC/MAR-BIO/4694/2014] Funding Source: FCT

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According to the World Health Organization, the exacerbated use of antibiotics worldwide is increasing multi-resistant infections, especially in the last decade. Xanthones are a class of compounds receiving great interest in drug discovery and development that can be found as natural products or obtained by synthesis. Many derivatives of xanthones are chiral and associated with relevant biological activities, including antimicrobial. The aim of this review is to compile information about chiral derivatives of xanthones from natural sources and their synthesized examples with antimicrobial activity.

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