Journal
MOLECULES
Volume 23, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules23102530
Keywords
Imidazoles; phenolic compounds; antifungal activity; MIC; antioxidant capacity; structure-activity relationship
Funding
- Portuguese Fundacao para a Ciencia e Tecnologia [PPCDT/QUI/59356]
- Portuguese FCT [SFRH/BPD/26106]
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A selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes 3 was synthesized and cyclized to 2-aryl-4,5-dicyano-1H-imidazoles 4 upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested for their antioxidant capacity by cyclic voltammetry, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and deoxyribose degradation assays. The minimum inhibitory concentration of all compounds was evaluated against two yeast species, Saccharomyces cerevisiae and Candida albicans. Their toxicity was tested in mammal fibroblasts. Among the synthesised compounds, two presented dual antioxidant/antifungal activity without toxic effects in fibroblasts. The new compounds synthesized in this work are potential biochemical tools and/or therapeutic drugs.
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