4.6 Review

Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics

Journal

MOLECULES
Volume 23, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/molecules23112757

Keywords

HSF1; HSPs; HSF1 inhibitors; anticancer agents

Funding

  1. National Research Foundation (NRF) - Ministry of Education, Republic of Korea [NRF-2016R1A6A1A03011325, 2016R1D1A1B01009559]
  2. Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [116102-03]

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Targeted therapy is an emerging paradigm in the development of next-generation anticancer drugs. Heat shock factor 1 (HSF1) has been identified as a promising drug target because it regulates several pathways responsible for cancer cell growth, metastasis, and survival. Studies have clearly demonstrated that HSF1 is an effective drug target. Herein, we provide a concise yet comprehensive and integrated overview of progress in developing small molecule inhibitors of HSF1 as next-generation anticancer chemotherapeutics while critically evaluating their potential and challenges. We believe that this review will provide a better understanding of important concepts helpful for outlining the strategy to develop new chemotherapeutic agents with promising anticancer activities by targeting HSF1.

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