Journal
MOLECULES
Volume 23, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules23102692
Keywords
chiral base; 1,4-dihydropyridine; enantioselective; hydrazone; organocatalysis
Funding
- Ministerio de Economia, Industria y Competitividad [CTQ2017-88091-P]
- Universidad de Zaragoza [JIUZ-2017-CIE-05]
- Gobierno de Aragon-Fondo Social Europeo [E07_17R]
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Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of beta-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40-54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.
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