Journal
MOLECULAR PHARMACEUTICS
Volume 16, Issue 3, Pages 987-994Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.8b00862
Keywords
combination cancer therapy; GSH-responsive; prodrug micelle; DOX delivery
Funding
- National Natural Science Foundation of China [81772665, 81502153, 81472345]
- Natural Science Foundation of Jiangsu Province [BK20150221]
- China Postdoctoral Science Foundation [2016M591926, 2017T100409]
- Jiangsu Province, Key Research & Development Plan of Jiangsu Province [BE2016646]
- Jiangsu provincial Commission of Health and Family Planning [Q201608]
- Six Talents Peak Foundation of Jiangsu Province [2018-WSW-071]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX17_1733]
Ask authors/readers for more resources
A combination of different chemotherapy approaches can obtain the best response for many cancers. However, the greatest challenge is the development of a nanoparticle formulation that can encapsulate different chemotherapeutic agents to achieve the proper synergetic chemotherapy for the tumor. Here, amphiphilic ferrocenium-tetradecyl (Fe-C-14) was constructed to form cationic micelles in an aqueous solution via self-assembly. Then, it was coated by hyaluronic acid (HA) through electrostatic interactions to generate HA Fe-C-14 micelles. The HA Fe-C-14 micelles were used to deliver doxorubicin (DOX), and it showed that the DOX could be released rapidly under a high-GSH tumor environment. The HA Fe-C-14/DOX micelles were able to accumulate efficiently in tumor and showed significant anticancer effect both in vitro and in vivo. These results suggest that HA-Fe-C-14/DOX micelles are a useful drug delivery system that enhances synergic antitumor treatment effects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available