Journal
MOLECULAR PHARMACEUTICS
Volume 16, Issue 2, Pages 552-560Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.8b00836
Keywords
3D printing; poloxamer; paclitaxel; ovarian cancer; peritoneal adhesion
Funding
- St. Louis College of Pharmacy Faculty Research Incentive Fund
- Fairleigh Dickinson University Provost Seed Grant
- NIH [P50 CA094056]
Ask authors/readers for more resources
Nanogels are attractive biocompatible materials that enable local delivery of multiple drugs. In this study, we demonstrated that 3D printing technology could be used to precisely construct nanogel discs carrying paclitaxel and rapamycin. 3D-printed nanogel disc rounds (12 mm diameter x 1 mm thickness) carrying paclitaxel and rapamycin evaded premature gelation during storage and the initial burst release of the drugs in the dissolution medium. In vivo 3D-printed nanogel discs permitted successful intraperitoneal delivery of paclitaxel and rapamycin in ES-2-luc ovarian-cancer-bearing xenograft mice. They were also shown to be therapeutically effective and capable of preventing postsurgical peritoneal adhesions in the treated xenograft mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available