Journal
MOLECULAR NEUROBIOLOGY
Volume 56, Issue 7, Pages 4880-4893Publisher
SPRINGER
DOI: 10.1007/s12035-018-1403-3
Keywords
Ferroptosis; Brain disease; Stroke; Cancer
Categories
Funding
- American Heart Association [17POST33660191, 16SDG30980031]
- Scientific Research Program of Beijing Municipal Commission of Education [KM201710025005]
- National Institutes of Health [R21NS102899]
- Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, John Hopkins University
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Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer's disease, and Parkinson's disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.
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