Journal
MOLECULAR CARCINOGENESIS
Volume 58, Issue 5, Pages 674-685Publisher
WILEY
DOI: 10.1002/mc.22960
Keywords
biomarker; breast cancer; CD82; KAI1; exosomes; liquid biopsy
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Funding
- National Natural Science Foundation of China [81401738, 81601619]
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CD82, a member of the tetraspanin superfamily, has been proposed to exert its activity via tetra-transmembrane protein enriched microdomains (TEMs) in exosomes. The present study aimed to explore the potential of the exosome protein CD82 in diagnosing breast cancers of all stages and various histological subtypes in patients. The results strongly suggest that CD82 expression in breast cancer tissue was significantly lower than that in healthy and benign breast disease tissues. There was a significant negative correlation between CD82 expression in tissues and CD82 content in exosomes, which indicated that CD82 expression was redistributed from tissues to the blood with the development and metastasis of breast cancer.
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