Journal
MOLECULAR BIOLOGY REPORTS
Volume 46, Issue 1, Pages 1401-1411Publisher
SPRINGER
DOI: 10.1007/s11033-018-4496-x
Keywords
Telomerase; Cancer; Telomeres; hTERT
Categories
Funding
- National Science Centre [2016/21/B/NZ7/01079]
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Telomerase is perceived as an immortality enzyme that enables passing the Hayflick limit. Its main function is telomere restoration but only in a limited group of cells, including cancer cells. Since it is found in a vast majority of cancer cells, it became a natural target for cancer therapy. However, it has much more functions than just altering the metabolism of telomeres-it also reveals numerous so-called non-canonical functions. Thus, a question arises whether it is always beneficial to turn it off when planning a cancer strategy and considering potential side effects? The purpose of this review is to discuss some of the recent discoveries about telomere-independent functions of telomerase in the context of cancer therapy and potential side effects.
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