Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 480, Issue -, Pages 122-132Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2018.10.021
Keywords
Dermatopontin; Papillary thyroid cancer; Proliferation; MYC; ERK
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Funding
- National Natural Science Foundation of China [81572623, 81572624, 81602347]
- Natural Science Foundation of Guangdong Province [2016A030310169]
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Dermatopontin (DPT), a noncollagenous extracellular matrix component, has been illustrated to regulate cellular proliferation and invasiveness in several types of neoplasms. Nevertheless, the biological functions of DPT in cell proliferation, especially papillary thyroid cancer (PTC) cell proliferation, remain unknown, as do the mechanisms underlying its effects. In this study, we detected low DPT expression in PTC, which was related to higher T classifications. Ectopic DPT expression impeded cell proliferation both in vitro and in vivo. Furthermore, we illustrated that DPT down-regulated MYC, which in turn targeted CDK4, CDK6 and p21, through the ERK pathway. These results suggest that DPT regulates CDK4, CDK6 and p21, through MEK-ERK-MYC signaling to repress PTC proliferation.
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