Journal
MOLECULAR & CELLULAR TOXICOLOGY
Volume 15, Issue 1, Pages 103-109Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
DOI: 10.1007/s13273-019-0012-1
Keywords
alpha-Synuclein (-SYN); Small ubiquitin-related modifier proteins (SUMO); Karyopherin (KPNA)
Categories
Funding
- National Research Foundation of Korea, SGER [NRF-2017R1D1A1A02019443]
Ask authors/readers for more resources
Backgrounds-Synuclein (-SYN) is uniquely found in the brains of Parkinson's disease (PD) patients and it has been the major target of PD research for many years. The translocation of -SYN into the nucleus of neuronal cells is a well-known fact but the mode of nuclear entry and its functions thereafter are not well defined.MethodsBy utilizing a model cell line and primary cultured neurons, we have investigated a plausible mechanism of -SYN nuclear translocation and its pathophysiological roles in the nucleus of cells with neuronal phenotypes.ResultsWe, first, identified that cytosolic -SYN proteins bind to karyopherin alpha6 proteins only after sumoylation (i.e. SUMO2/3 binding) and then transits through the nuclear pore complex (NPC) as a complexed entity.ConclusionWe investigated that the nuclear translocation of -SYN is critically required for its nuclear translocation and that this process is mediated by karyopherin alpha6.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available