Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 19, Issue 2, Pages 125-137Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557518666181017143141
Keywords
Traditional Chinese Herbal Medicine (TCHM); drug-resistant bacteria; TCHM-derived compounds; antibacterial effect; shigellosis; tuberculosis
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Funding
- National Major Drug Discovery Project [2015ZX09J15102-004]
- twelveth Five-Year Plan foundation of China people's Liberation Army [CWS11C164]
- National Natural Science Foundation of China [81173571]
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Infectious diseases caused by pathogenic bacteria seriously threaten human lives. Although antibiotic therapy is effective in the treatment of bacterial infections, the overuse of antibiotics has led to an increased risk of antibiotic resistance, putting forward urgent requirements for novel antibacterial drugs. Traditional Chinese herbal medicine (TCHM) and its constituents are considered to be potential sources of new antimicrobial agents. Currently, a series of chemical compounds purified from TCHM have been reported to fight against infections by drug-resistant bacteria. In this review, we summarized the recent findings on TCHM-derived compounds treating drug-resistant bacterial infections. Further studies are still needed for the discovery of potential antibacterial components from TCHM.
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