Journal
MICROPOROUS AND MESOPOROUS MATERIALS
Volume 274, Issue -, Pages 304-312Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micromeso.2018.09.001
Keywords
Hollow mesoporous silica; Hydrotalcite; pH-sensitivity drug release; Kinetics
Categories
Funding
- Joint Research Program of Hunan Provincial Natural Science Foundation (Xiangtan) of China [2016JJ5030]
- Hunan 2011 Collaborative Innovation Center of Chemical Engineering & Technology with Environmental Benignity and Effective Resource Utilization
- General project of Hunan Provincial Education Department [17C1526]
- PhD Startup Foundation of Xiangtan University [17QDZ05]
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Hollow mesoporous silica (HMS) composed of a hollow cavity and mesoporous shell available for drug storage. The MgAl-LDH as a gatekeeper coated on the HMS outer surface by the layer-by-layer selfassembly method, encapsulated the anticancer drug 5-Fluorouracil (5-FU) within the HMS cavities and pores to get the pH-controlled drug release system (FU/HMS@LDH) for minimizing premature release of 5-FU. The structures, morphology, texture and 5-FU release behavior were characterized and investigated with various techniques. The kinetic data revealed that the targeted 5-FU release by the LDH-gated HMS release system (FU/HMS@LDH) stemmed from the dissolution of the LDH nanosheets upon decrease in pH and cleavage of the hydrogen bonds, indicating that the pH-responsive controlled release of 5-FU could be stimulated by acidic environments. These results suggested that the FU/HMS@LDH release system had the potential as an anticancer drug delivery system in targeted drug release for tumor chemotherapy.
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