Journal
MICROCHIMICA ACTA
Volume 185, Issue 12, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-018-3098-6
Keywords
TNT; Aptasensor; AgNPs; Electrodeposition; Aptasensig assay
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Funding
- Ilam University
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An electrochemical nanoaptasensor is described that is based on the use of a glassy carbon electrode (GCE) modified with electrodeposited silver nanoparticles (AgNPs). An aptamer (Apt) against trinitrotoluene (TNT) was then immobilized on the AgNPs. The addition of TNT to the modified GCE leads to decrease in peak current (typically measured at a potential of -0.45V vs. Ag/AgCl) of riboflavin which acts as an electrochemical probe. Even small changes in the surface (as induced by binding of Apt to TNT) alter the interfacial properties. As a result, the LOD is lowered to 33 aM, and the dynamic range extends from 0.1 fM to 10M without sacrificing specificity.
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