Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 49, Pages 33377-33385Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b06075
Keywords
ultrathin film (nanosheet); thermometry; heat production; optical sensor; luminescent
Funding
- A*STAR-JST (Agency for Science, Technology and Research, Singapore)
- A*STAR-JST (Japan Science and Technology Agency, Japan) [M4070198]
- MOE Academic Research Fund in Singapore [RG41/15]
- JSPS Core-to-Core Program
- JSPS KAKENHI from MEXT, Japan [15H05355, 16K14009]
- Precursory Research for Embryonic Science and Technology (PRESTO) from the Japan Science and Technology Agency, Japan [15655478]
- Mizuho Foundation for the Promotion of Sciences
- Grants-in-Aid for Scientific Research [16K14009, 15H05355] Funding Source: KAKEN
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In this paper, a microthermograph, temperature mapping with high spatial resolution, was established using luminescent molecules embedded ultrathin polymeric films (nanosheets), and demonstrated in a living small animal to map out and visualize temperature shift due to animal's muscular activity. Herein, we report super flexible and self-adhesive (no need of glue) nanothermosensor consisting of stacked two different polymeric nanosheets with thermosensitive (Eu-tris (dinaphthoylmethane)-bis-trioctylphosphine oxide: EuDT) and insensitive (Rhodamine 800) dyes being embedded. Such stacked nanosheets allow for the ratiometric thermometry, with which the undesired luminescence intensity shift due to focal drift or animal's z-axis displacement is eliminated and the desired intensity shift solely due to the temperature shift of the sample (living muscle) can be acquired. With the stacked luminescent nanosheets, we achieved the first-ever demonstration of video filming of chronologically changing temperature-shift distribution from the rest state to the active state of the muscles in the living animal. The polymer nanosheet engineering and in vivo microthermography presented in the paper are promising technologies to microscopically explore the heat production and heat transfer in living cells, tissues, and organisms with high spatial resolution beyond what existing thermometric technologies such as infrared thermography have ever achieved.
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